A greedier approach for finding tag SNPs
نویسندگان
چکیده
منابع مشابه
A greedier approach for finding tag SNPs
MOTIVATION Recent studies have shown that a small subset of Single Nucleotide Polymorphisms (SNPs) (called tag SNPs) is sufficient to capture the haplotype patterns in a high linkage disequilibrium region. To find the minimum set of tag SNPs, exact algorithms for finding the optimal solution could take exponential time. On the other hand, approximation algorithms are more efficient but may fail...
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هدف اصلی از این تحقیق به دست آوردن و مقایسه حق بیمه باورمندی در مدل های شمارشی گزارش نشده برای داده های طولی می باشد. در این تحقیق حق بیمه های پبش گویی بر اساس توابع ضرر مربع خطا و نمایی محاسبه شده و با هم مقایسه می شود. تمایل به گرفتن پاداش و جایزه یکی از دلایل مهم برای گزارش ندادن تصادفات می باشد و افراد برای استفاده از تخفیف اغلب از گزارش تصادفات با هزینه پائین خودداری می کنند، در این تحقیق ...
15 صفحه اولEfficient selective screening of haplotype tag SNPs
UNLABELLED Haplotypes defined by common single nucleotide polymorphisms (SNPs) have important implications for mapping of disease genes and human traits. Often only a small subset of the SNPs is sufficient to capture the full haplotype information. Such subsets of markers are called haplotype tagging SNPs (htSNPs). Although htSNPs can be identified by eye, efficient computer algorithms and flex...
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Recent studies have shown that the chromosome recombination only takes places at some narrow hotspots. Within segments between these hotspots, called haplotype block, little or even no recombination occurs and a small subset of SNPs, called tag SNPs, are sufficient to capture the entire block pattern. However, the tag SNP may be genotyped as missing data if it does not pass the threshold of dat...
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Single Nucleotide Polymorphisms (SNPs) are common among human populations. SNPs that are proximally located within a small human chromosome region are generally strongly correlated that a subset of SNPs, termed tag SNPs, can provide enough information to infer neighboring SNPs. Such correlations are generally known as linkage disequilibrium (LD) and are measured either pair-wise, such as r, or ...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2006
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btk035